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DeCS
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Descriptor English:
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Receptors, Death Domain
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Descriptor Spanish:
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receptores de dominios de muerte
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Descriptor Portuguese:
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Receptores de Morte Celular
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Synonyms English:
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DR Family Receptors
Death Domain Receptors
Death Receptors
Receptors, DR Family
Receptors, Death Domain Family
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Tree Number:
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D12.776.543.750.690
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Definition English:
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A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES. |
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See Related English:
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Receptors, Tumor Necrosis Factor
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History Note English:
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2007
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Allowable Qualifiers English:
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Record Number:
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52336
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Unique Identifier:
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D053218
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Occurrence in VHL:
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Similar:
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DeCS
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